Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-induced nitric oxide release

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Guangming Xu, Zheming Wang, Biqing Zhao, Nianzheng Liu, Shenghui Yang, Yonghong Liu, Junfeng Wang, Xiaojiang Zhou Two new flavonoids, saniculamins A and B (1 and 2), together with three known flavonoid derivatives brosimacutin (3), 6-flavonol (4), and eucomol (5) were isolated from the whole plants of Sanicula lamelligera Hance collected in Mountain Emei, Sichuan Province, People’s Republic of China. The structures of all isolated compounds were determined on the basis of extensive spectroscopic analyses, including 1D/2D NMR, and HRMS data, as well as by comparison with literature reports. Compounds 1–3 exhibited the inhibitory effects on LPS-induced nitric oxide production with IC50 values of 2.31, 4.48 and 16.52μM, respectively. Graphical abstract

Source: Phytochemistry Letters - September 2, 2016 Category: Chemistry Source Type: research