Bioactive cucurbitane triterpenoids from the tubers of Hemsleya penxianensis

Publication date: December 2016 Source:Phytochemistry Letters, Volume 18 Author(s): Ye-Dan Li, Si-Rong Yi, Xiao-Bo Sun, Xing-Yang Zhou, Hong-Yang Zhang, Yun-Qing Wang, Jun-Shan Yang, Xu-Dong Xu, Guo-Xu Ma Four new cucurbitacins, jinfushanencins C-F (1–4) and three known analogues (5–7) were isolated from the tubers of Hemsleya penxianensis by Silica gel column, ODS column, pre-HPLC techniques. The structures of 1–7 were establishhed on the basis of extensive spectroscopic. The isolated compounds were tested for their cytotoxic activity against Hela human cancer cell line and compounds 1, 5, and 7 showed significant cytotoxicity with IC50 values at 5.1, 8.7, and 1.2 μM, respectively. None of the compounds had active anti-HIV activity. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research