Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo.

In conclusion, extracellular calcium and 1,25(OH)2D3 regulate sebocyte morphology, increase cell numbers, decrease sebaceous lipogenesis and induce cell autophagy in vitro. The increased ionized calcium and the reduced 1,25(OH)2D3 levels detected in the serum of younger patients with acne may contribute respectively to increased sebaceous gland volume and enhanced lipogenesis.
PMID: 27572620 [PubMed - as supplied by publisher]

Source: Acta Dermato-Venereologica - August 29, 2016 Category: Dermatology Authors: Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, Kubba R Tags: Acta Derm Venereol Source Type: research