Single-Cell RNA-Seq Allows Deep Analysis of the Tumor Immune Microenvironment and Alterations Induced by Anti-PD-1 Treatment
Despite the impressive clinical results seen with immune checkpoint inhibitors, we have only a limited understanding of the immunologic changes within the tumor microenvironment that result from checkpoint blockade. A deeper understanding of the treatment effects on the microenvironment is required to predict which patients will respond, develop adjuvant agents to increase response rates, and discover the next generation of immune modulating therapies.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Brian Miller, Marc Wadsworth, Kevin Bi, Travis Hughes, Arlene Sharpe, Alex Shalek, W. Haining Source Type: research