Six new dihydrobenzofuran lignans from the branches and leaves of Illicium wardii and their cytotoxic activities

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Feng-mei Ye, Yang-guo Xie, Jie Ren, Ji Ye, Yi-gong Guo, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang Six new dihydrobenzofuran lignans, named illiciumlignans A–F (compounds 1–6), along with 15 known compounds (7–21) were isolated from the branches and leaves of Illicium wardii. The structures of 1–6 were determined using a combination of 1D and 2D NMR, HR-ESI–-MS, and CD spectroscopic data. Illiciumlignan D (4) is the first reported dihydrobenzofuran lignan arabinofuranoside that is derivatized with the arabinofuranose moiety on C-9′. Compounds 1–21 were evaluated for cytotoxic activity against four human cancer cell lines. Compounds 8, 12 and 20 exhibited significant activity against human cancer cell lines (A549, SKOV3, HepG2 and HCT116), with IC50 values ranging from 2.7 to 14.9μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research