Prevalence of PPAR- γ2 (rs1801282), RETN (rs3745367) and ADIPOQ (rs2241766) SNP markers in the Bangladeshi Type 2 Diabetic Population

Publication date: Available online 10 August 2016 Source:Meta Gene Author(s): Razwa Saleh, Zahidul Islam Zahid, Mohammad Atikur Rahman, Preeti Jain, Ashraful Alam, Hasan Mahmud Reza, Masashi Kawaichi The genetic variants within peroxisome- proliferator activated receptor-gamma 2 (rs1801282), resistin (rs3745367) and adiponectin (rs2241766) were examined in this pilot study to find a possible link between the single nucleotide polymorphisms (SNPs) and type 2 diabetes mellitus (T2D) in the Bangladeshi population. The correlation between frequency of SNPs in the aforementioned genes with biochemical and demographic traits related to T2D were also assessed. A total of 95 subjects (diabetic and normal glucose tolerant) were considered for the study and genotyping was done using the restriction fragment length polymorphism technique. The PPAR-γ2 and adiponectin polymorphisms did not show any significant predisposition to diabetics where as the resistin gene polymorphism was significantly associated in terms of higher prevalence in diabetics over control individuals (P =0.026, OR=2.185, 95% CI=1.092–4.375). The PPAR-γ2 polymorphism was related to higher fasting plasma glucose and HbA1c levels within the diabetic population but not within controls. The inheritance of the RETN polymorphism was related to higher LDL (P =0.01) at 5% significance levels. For PPAR-γ2 the homozygous polymorphic genotype was absent in diabetic population while the heterozygote genotype was abs...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research