The SMAD pathway is required for hepcidin response during endoplasmic reticulum stress.

In conclusion, our study indicates that hepcidin induction by ER stress involves the central regulatory SMAD1/5 pathway.
PMID: 27483343 [PubMed - as supplied by publisher]

Source: Endocrinology - August 1, 2016 Category: Endocrinology Authors: Canali S, Vecchi C, Garuti C, Montosi G, Babitt JL, Pietrangelo A Tags: Endocrinology Source Type: research