Is It Time to Use De Novo mTOR Inhibitors Posttransplant?

Abstract The use of mTOR inhibitors evokes debate in transplantation. Numerous clinical trials have explored the role of the mTOR inhibitors sirolimus and everolimus in kidney transplantation, but the results have been mixed; they have not shown a clear benefit over the current regimens. However, many of these trials were impacted by the difficulties and uncertainties in managing side effects and the dosing of the mTOR inhibitors. Being aware of the effective treatments available for these side effects, understanding the pathophysiology of the mTOR pathway allows patients to remain on therapy. Successful side effect management means that the longer term, advantageous benefits of mTOR inhibition can be gained by the kidney recipient and means that it is time to use de novo mTOR inhibitors in kidney recipients.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Source: Inflammation - Category: Allergy & Immunology Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Tags: Corrigendum Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Image Source Type: research
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Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Abstract from the 2019 New England Society for Vascular Surgery Annual Meeting Source Type: research
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Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
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Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
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Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
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Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
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Source: RAND Research Health and Health Care - Category: Health Management Authors: Source Type: research
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