Intracranial evaluation and laser ablation for epilepsy with periventricular nodular heterotopia

The disruption of radial neuronal migration during brain development results in malformations composed of heterotopic gray matter [1]. These may form continuous bands (laminar heterotopia) or discrete nodules, either in subcortical or periventricular locations (periventricular nodular heterotopia, PVNH). PVNH typically resides along the walls of the ventricular trigone, either unilaterally or bilaterally [2]. Nodular heterotopia is often associated with other types of cortical malformation, including polymicrogyria (PMG) [3] and focal cortical dysplasia [4], and is a common cause of refractory focal epilepsy [5,6].

Source: Seizure: European Journal of Epilepsy - July 14, 2016 Category: Neurology Authors: Stephen A. Thompson, Giridhar P. Kalamangalam, Nitin Tandon Tags: Review Source Type: research