Common interventional techniques (single versus combined) in management of hepatocellular carcinoma

Conclusion: The study showed that combined therapy achieved better results regarding complete response and overall survival rate than RF or TACE alone.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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Publication date: Available online 24 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Maya W. Haaker, Arie B. Vaandrager, J. Bernd HelmsAbstractVitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the immune response and the development of metabolic syndrome. Most of the retinol present in the body is stored as retinyl esters within lipid droplets in hepatic stellate cells (HSCs). In case of liver damage, HSCs release large amounts of stored retinol, which is partially converted to retinoic acid (RA). This surge of RA can med...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.0c00331
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
To assess the feasibility of transarterial chemoembolization with drug-eluting embolic (DEE) microspheres in a woodchuck model of hepatocellular carcinoma (HCC).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Laboratory Investigation Source Type: research
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Source: Cell Cycle - Category: Cytology Authors: Source Type: research
Authors: Zhang Y, Ying X, Zhao Q, Ma J, Zhang D, He C, Han S Abstract Background: Hepatocellular carcinoma (HCC) is a malignant tumor associated with a poor prognosis. Serum biomarkers of HCC have the potential to improve the diagnosis, provide a means to monitor the tumors, and predict their malignancy. Proteins that are expressed differentially between HCC patients and normal controls have the potential to be biomarkers. Method: Serum samples from 10 confirmed HCC patients and 10 controls were collected. The differentially expressed proteins in the serum were identified using an isobaric tags for relative and...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Authors: Yasuda D, Ohe T, Takahashi K, Imamura R, Kojima H, Okabe T, Ichimura Y, Komatsu M, Yamamoto M, Nagano T, Mashino T Abstract Resistance to anticancer agents has been an obstacle to developing therapeutics and reducing medical costs. Whereas sorafenib is used for the treatment of human hepatocellular carcinoma (HCC), resistance limits its efficacy. p62, a multifunctional protein, is overexpressed in several HCC cell lines, such as Huh-1 cells. Phosphorylated p62 (p-p62) inhibits the protein-protein interaction (PPI) between Keap1 and Nrf2, resulting in the Nrf2 overactivation that causes drug resistance. We ...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Publication date: Available online 21 February 2020Source: European Journal of RadiologyAuthor(s): Mathis Eichler, Matthias May, Marco Wiesmueller, Marc Saake, Rafael Heiss, Michael Uder, Wolfgang WuestAbstractPurposeAim of this study was to evaluate image quality of single source dual energy CT (SSDE-CT) using split filter technique in oncologic abdominal CT.Method51 consecutive patients with newly diagnosed breast carcinoma were prospectively enrolled in this study and underwent a staging examination of the abdomen using SSDE-CT (120 kV, split filter technique, 400 ref. mAs). Inline default images (DI) and post-pr...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsLI-RADS shows high diagnostic accuracy in diagnosing of HCC with a pooled sensitivity of 0.86 and specificity of 0.85, and specificity is higher for LR-5 or LR ≥ 5. However, further prospective studies of LI-RADS are needed to elucidate its value for diagnosing of small HCCs (≤20 mm).
Source: European Journal of Radiology - Category: Radiology Source Type: research
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Source: Expert Opinion on Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research
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