Inhibition of T-cell activation by CTLA4-Fc is sufficient to ameliorate proteinuric kidney disease.
In this study we used the soluble CTLA4-Fc fusion protein Abatacept to block cell surface B7-1, preventing the cellular interaction and inhibiting T-cell activation. When Abatacept was dosed in an animal model of diabetes-induced albuminuria, it reduced albuminuria in both prevention and intervention modes. The number of T-cells infiltrating the kidneys of DN animals correlated with the degree of albuminuria and treatment with Abatacept reduced the number of renal T-cells. As B7-1 induction has been recently proposed to underlie podocyte damage in DN, Abatacept could be efficacious in DN by protecting podocytes. However, this does not appear to be the case as B7-1 was not expressed in: 1) kidneys of DN animals; 2) stimulated human podocytes in culture; or 3) glomeruli of DN patients. We conclude that Abatacept ameliorates DN by blocking systemic T-cell activation and not by interacting with podocytes. PMID: 27440778 [PubMed - as supplied by publisher]
Conclusions: Our findings provide new evidence on patterns of behavioral modification in a population-based sample of Latinos diagnosed with chronic health conditions. Findings suggest the need to promote language and culturally relevant initiatives to increase the adoption of health-enhancing behaviors and improve chronic disease management among Spanish-speaking Latinos.
Journal of Medicinal Food, Ahead of Print.
Compared with placebo, critically ill, vitamin D-deficient patients did not appear to gain any benefit from receiving high-dose vitamin D in the ICU.Medscape Medical News
CONCLUSION: polypharmacy study becomes an opportunity to guide the strategies for the patient safety to promote the medication without harm in chronic diseases. PMID: 31826159 [PubMed - in process]
CONCLUSION: Single male adolescents with lower level of education and high glycated hemoglobin levels were more likely to have lower health-related quality of life. PMID: 31826155 [PubMed - in process]
CONCLUSIONS: MS was significantly associated with IMT and the presence of carotid plaque and with positively increased risks of MI, stroke, and CVD mortality independent of CVD risk factors in older Chinese adults. PMID: 31826385 [PubMed - in process]
Pacific Diabetes Technologies is building a combined infusion set and continuous glucose monitoring sensor for people with diabetes.
What do we currently know about the long-term safety and efficacy of recombinant human parathyroid hormone treatment in patients with hypoparathyroidism?Journal of Clinical Endocrinology &Metabolism
What is the association between preconception serum leptin concentrations and fecundability?Journal of the Endocrine Society
Conditions: Obesity; Diabetes Mellitus, Type 2 Interventions: Procedure: Short BPL RYGB; Procedure: Long BPL RYGB Sponsors: Hospital de Sao Sebastiao; Instituto de Ciências Biomédicas Abel Salazar; The Novo Nordisk Foundation Center for Basic Metabolic Research Recruiting