Correlation Between Advanced Glycation End ‐Products, Lower Urinary Tract Symptoms and Bladder Dysfunctions in Patients with type 2 Diabetes Mellitus
ObjectivesTo explore whether serum and urinary advanced glycation end‐products (AGEs) are related to urinary symptoms and bladder dysfunctions in diabetic patients. MethodsForty‐seven patients with type 2 Diabetes mellitus (T2DM) and lower urinary tract symptoms (LUTS) were enrolled. LUTS evaluation was performed by IPSS (International Prostatic Symptoms Score), QoL (quality of life), OAB (overactive bladder). ICI‐SF (International Consultation on Incontinence – short form) quaestionneires; ultrasound examination, evaluation of postvoid residual (PVR), uroflowmetry, cystometry with pressure‐flow study (PFS) were performed to detect bladder dysfunctions. Serum and urinary AGEs were quantified by ELISA method. ResultsPatients were divided into four subgroups: (i) normal‐detrusor‐contractility + normal‐ detrusor‐activity (1 ♂ [4.8%] and 4 ♀ [21%]), (ii) impaired‐detrusor‐contractility + normal‐detrusor‐ activity (4 ♂ [19.1%] and 0 ♀), (iii) normal‐detrusor‐contractility + detrusor‐overactivity (1 ♂ [4.8%] and 6 ♀ [31.6%]), (iv) impaired‐detrusor‐contractility + detrusor‐overactivity (15 ♂ [71.4%] and 9 ♀ [47.4%]). Serum AGEs were 12.2 ± 5.5 in men and 10.4 ± 5.6 in women; urinary AGEs were 1.5 ± 1.1 in men and 2.5 ± 1.6 in women. Serum AGEs exhibited a positive correlation w...
Publication date: Available online 24 September 2020Source: Microvascular ResearchAuthor(s): Lauren Van Hove, Kirsten R. Kim, Denise M. Arrick, William G. Mayhan
Authors: Li L, Sun W, Han M, Ying Y, Wang Q Abstract BACKGROUND Early and rapid identification of severe coronavirus disease 2019 (COVID-19) cases is important. The present study aimed to investigate the predictors of disease severity and thus determine the trends for disease progression early. MATERIAL AND METHODS Patients with COVID-19 were recruited from Fuyang Second People's Hospital from January to February 2020. Patients' demographic, epidemiological, and clinical data were collected, and the relationships between these variables and disease severity were analyzed. RESULTS A total of 158 cases were included ...
No abstract available
No abstract available
Condition: Diabetes Mellitus, Type 2 Interventions: Drug: HSK7653 10 mg Q2W; Drug: HSK7653 25 mg Q2W; Drug: Linagliptin 5 mg QD Sponsor: Sichuan Haisco Pharmaceutical Group Co., Ltd. Not yet recruiting
Condition: Diabetes Mellitus, Type 2 Interventions: Drug: ORMD-0801; Other: Placebo Sponsor: Oramed, Ltd. Not yet recruiting
CONCLUSIONS: T2DM mice exhibited the early phase of diabetic bladder dysfunction (DBD) characterized by OAB and bladder dysfunction. SQW can improve the bladder storage and micturition of DBD mice by mediating the protein and gene expression levels of myosin Va and SLC17A9 in the bladder, instead of improving the blood glucose level.
Authors: Tanik N, Tanik S, Albayrak S, Zengin K, Inan LE, Caglayan EK, Celikbilek A, Kirboga K, Gurdal M Abstract PURPOSE: Diabetes mellitus (DM) is a chronic metabolic disorder that often leads to complications. We aimed to correlate two complications of DM, polyneuropathy and hyperactive bladder syndrome, using noninvasive measures, such as screening tests. METHODS: We included 80 female and 40 male type 2 diabetic patients in this prospective study. Diabetic polyneuropathy evaluations were conducted using the Douleur Neuropathique 4 Questions (DN4), and overactive bladder (OAB) evaluations were performed usi...
Conclusions The presence of nocturia was associated with erectile dysfunction, systemic vascular events, higher mortality, and indicated poor health in male with type 2 diabetic mellitus.
W. J. Bang, J. Y. Lee, K. C. Koo, Y. S. Hah, D. H. Lee and K. S. Cho