Correlation Between Advanced Glycation End ‐Products, Lower Urinary Tract Symptoms and Bladder Dysfunctions in Patients with type 2 Diabetes Mellitus

ObjectivesTo explore whether serum and urinary advanced glycation end‐products (AGEs) are related to urinary symptoms and bladder dysfunctions in diabetic patients. MethodsForty‐seven patients with type 2 Diabetes mellitus (T2DM) and lower urinary tract symptoms (LUTS) were enrolled. LUTS evaluation was performed by IPSS (International Prostatic Symptoms Score), QoL (quality of life), OAB (overactive bladder). ICI‐SF (International Consultation on Incontinence – short form) quaestionneires; ultrasound examination, evaluation of postvoid residual (PVR), uroflowmetry, cystometry with pressure‐flow study (PFS) were performed to detect bladder dysfunctions. Serum and urinary AGEs were quantified by ELISA method. ResultsPatients were divided into four subgroups: (i) normal‐detrusor‐contractility + normal‐ detrusor‐activity (1 ♂ [4.8%] and 4 ♀ [21%]), (ii) impaired‐detrusor‐contractility + normal‐detrusor‐ activity (4 ♂ [19.1%] and 0 ♀), (iii) normal‐detrusor‐contractility + detrusor‐overactivity (1 ♂ [4.8%] and 6 ♀ [31.6%]), (iv) impaired‐detrusor‐contractility + detrusor‐overactivity (15 ♂ [71.4%] and 9 ♀ [47.4%]). Serum AGEs were 12.2 ± 5.5 in men and 10.4 ± 5.6 in women; urinary AGEs were 1.5 ± 1.1 in men and 2.5 ± 1.6 in women. Serum AGEs exhibited a positive correlation w...
Source: LUTS: Lower Urinary Tract Symptoms - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Source: Microvascular Research - Category: Biochemistry Source Type: research
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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Research Letter Source Type: research
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Condition:   Diabetes Mellitus, Type 2 Interventions:   Drug: HSK7653 10 mg Q2W;   Drug: HSK7653 25 mg Q2W;   Drug: Linagliptin 5 mg QD Sponsor:   Sichuan Haisco Pharmaceutical Group Co., Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Diabetes Mellitus, Type 2 Interventions:   Drug: ORMD-0801;   Other: Placebo Sponsor:   Oramed, Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
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Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
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Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Urological Survey Source Type: research
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