Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers

Conclusions: Plasma PGRN is relatively stable over 1 week and therefore seems suitable for treatment monitoring of PGRN-enhancing agents. Since plasma PGRN only moderately correlated with CSF PGRN, CSF sampling will additionally be needed in therapeutic trials.Dement Geriatr Cogn Disord Extra 2016;6:330-340
Source: Dementia and Geriatric Cognitive Disorders Extra - Category: Geriatrics Source Type: research