Comparison of Neurosensory Assessment Methods in Plastic Surgery
Abstract: Sensory assessment of the skin is essential to document the function of the sensory fibers of the tested nerves. The Semmes-Weinstein monofilaments, disk-criminator, electrodiagnostic testing, and Pressure-Specified Sensory Device (PSSD) have been currently used to assess sensory function of peripheral nerves. None of these methods is optimal because of different drawbacks; however, an increasing number of articles, which recognize the reliability of PSSD, have been published during the last decade. In this review, following a short overview on basic physiology and assessment methods of the skin sensory receptors, we compared the sensory assessment methods and summarized the applications of the PSSD in the field of different clinical areas, mainly peripheral neuropathies, breast, and flap surgery.
Publication date: Available online 12 September 2019Source: MitochondrionAuthor(s): Zhi-Rong Liu, Hai-Lin Dong, Yin Ma, Zhi-Ying WuAbstractMitochondrial trifunctional protein (MTP) deficiency is a rare autosomal recessive disorder with several phenotypes. Neuromyopathic form of MTP deficiency is characterized by infantile or juvenile-onset, progressive peripheral neuropathy and rhabdomyolysis. To date, only one Chinese patient harboring homozygous c. 739C>T (p.R247C) in HADHB has been reported. Here, using whole exome sequencing (WES), we identified a compound heterozygote of c.407T>C (p.M136T) and c.421G>A (p.A14...
Condition: Diabetic Neuropathies Intervention: Drug: CBD Sponsor: Pure Green Recruiting
Authors: Papanas N, Pafili K, Demetriou M, Chatzikosma G, Papachristou S, Papazoglou D PMID: 31509155 [PubMed - in process]
In conclusion, miR-23c may function as a new regulator to inhibit angiogenesis by targeting SDF-1α.Graphical abstract
Condition: Painful Diabetic Neuropathy Intervention: Biological: VM-202 Sponsors: Brigham and Women's Hospital; Helixsmith Co., Ltd. Not yet recruiting
Authors: Langsjoen PH, Langsjoen JO, Langsjoen AM, Rosenfeldt F Abstract CONTEXT: Heart failure (HF) is rapidly increasing in incidence and is often present in patients receiving long-term statin therapy. OBJECTIVE: To test whether or not patients with HF on long-term statin therapy respond to discontinuation of statin therapy and initiation of coenzyme Q10 (CoQ10) supplementation. DESIGN: We prospectively identified patients receiving long-term statin therapy in whom HF developed in the absence of any identifiable cause. Treatment consisted of simultaneous statin therapy discontinuation and CoQ10 supplemen...
New England Journal of Medicine, Ahead of Print.
Conclusion: Neurological morbidity commonly accompanies systemic vasculitis. Nervous system disease does not affect the survival significantly in these patients.
COBALT IS an essential trace element involved in vitamin B12 and myocardial metabolism. Although biologically necessary for normal physiologic function, cobalt can cause serious adverse health effects at high exposure levels.1 Several case reports of patients with metal-on-metal implants or occupational exposure have suggested that elevated serum cobalt levels may lead to a variety of different systemic symptoms or complications including neurologic (auditory and visual impairment, cognitive decline, peripheral neuropathy); cardiovascular (cardiomyopathy and arrhythmias); and endocrine (hypothyroidism) abnormalities.
CONCLUSION: Taking into account the current knowledge on the neurotropic vitamins B1, B6, and B12, we conclude that a biochemical synergy becomes apparent in many different pathways in the nervous system, particularly in the PNS as exemplified by their combined use in the treatment of peripheral neuropathy. PMID: 31490017 [PubMed - as supplied by publisher]