Will It Come Back?

Will it come back? We ponder that question. We obsess over that question. We analyze it to death. We dissect that question. We dream about that question. We have nightmares about that question. And no one can tell us anything.Once you get cancer, you never know if it will come back. Or when. That's what really sucks about cancer.I did read an article summary recently that discusses some indicators of when breast cancer might recur. A study was done to see if it could be determined which factors contributed to when breast cancer might come back. Some factors were determined to have impact and others not.A high grade tumor (meaning how aggressive it is on a scale of 1-3) is more likely to recur sooner as opposed to later. A hormone receptor sensitive tumor is more likely to recur later than an ER/PR- one. Smaller tumors were more likely to recur later than bigger ones. All of that sounds fairly logical.But what doesn't sound logical is that lymph node involvement, patient age, and menopausal status did not appear to correlate to when recurred. We do need to remember we are talking about 'when' it recurred as opposed to 'if' it recurred.I would have thought that the more nodes involved the sooner the recurrence. I had one tiny little lymph node in the cancer party so this does not help me at all. But otherwise, my tumor was grade 2, ER/PR+, and relatively small at 1.7 cm. So all this adds up to say that my cancer if it recurs is more likely to recur later. And sin...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: breast cancer cancer recurrence Source Type: blogs

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Women whose periods stop before the age of 40 are at greater risk of diabetes, heart disease, strokes, asthma and breast cancer, the study found. The UK menopause average is 51.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionEven though the number of cases was low, slight indications of an inverse association between coffee consumption and breast cancer risk among postmenopausal women were observed. Further longitudinal studies are warranted to confirm this finding.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
en Reynolds Wang There are little epidemiological data on the impact of persistent organic pollutants (POPs) and endocrine disruptors on mammographic density (MD), a strong predictor of breast cancer. We assessed MD in 116 non-Hispanic white post-menopausal women for whom serum concentrations of 23 commonly detected chemicals including 3 polybrominated diphenyl ethers (PBDEs), 8 per- and polyfluoroalkyl substances (PFASs), and 12 polychlorinated biphenyls (PCBs) had been measured. Linear regression analyses adjusting for potential confounders were used to examine the associations between the levels of the chemic...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Communication Source Type: research
CONCLUSIONS: Compared to women with no history of thyroid disorder, hypothyroidism was associated with a lower risk of breast cancer. This was mainly seen among those who received thyroid replacement therapy and had never used menopausal hormone therapy. Among the treatment options for hypothyroidism, levothyroxine had the strongest inverse association with breast cancer risk. PMID: 31918623 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Earlier onset of menarche is consistently noted as a risk marker for breast cancer. For example, risk of pre-menopausal breast cancer decreased by 9% for each year that menarche is delayed. Other pubertal milestones have also been associated with risk of breast cancer, including peak height velocity (PHV) and age of PHV. The hormonal environment, including sex steroids and growth hormone, change rapidly during puberty, and others have proposed the estrone:androstenedione ratio (E:A ratio) may provide an index of aromatase activity.
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Platform Research Presentation: Vaccines/Screening/Wellness Source Type: research
This study aimed to assess the rate of ovarian failure in a large cohort of Korean premenopausal patients with breast cancer 12 months after chemotherapy. Methods: This retrospective cohort study included premenopausal women (aged 20-44 years) with breast cancer who underwent chemotherapy after surgery. The rates of treatment-related amenorrhea (TRA) and chemotherapy-induced menopause (CIM) at 12 months after chemotherapy were analyzed. Results: A total of 237 patients met the inclusion criteria. The rate of TRA was 61.6% and that of CIM was 13.1% at 12 months after chemotherapy. The rates of TRA and CIM were 28.0%...
Source: Journal of Breast Cancer - Category: Cancer & Oncology Tags: J Breast Cancer Source Type: research
Abstract CONTEXT: Dense breast tissue is associated with 4-6 times higher risk of breast cancer by poorly understood mechanisms. No preventive therapy for this high-risk group is available. After menopause breast density decreases due to involution of the mammary gland. In dense breast tissue this process is haltered by undetermined biological actions. Growth hormone (GH) and insulin-like binding proteins (IGFBPs) play major roles in normal mammary gland development but their roles in maintaining breast density are unknown. OBJECTIVE: To reveal in vivo levels of GH, IGFBPs, and other pro-tumorigenic proteins ...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Endocrinol Metab Source Type: research
ConclusionWe identified several methodological concerns and limitations across epidemiological studies on potential risk factors for uterine/endometrial cancer in BCa survivors, including lack of details on uterine/endometrial cancer case ascertainment, varying and imprecise definitions of important covariates, insufficient adjustment for potential confounders, and small numbers of uterine/endometrial cancer cases in the overall as well as stratified analyses. Based on the available evidence, older age and higher body weight measures appear to be a shared risk factor for uterine/endometrial cancer in the general population...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionsBreast cancer risk among women with LCIS is impacted by breast density. These results aid in personalizing risk assessment among women with LCIS and highlight the importance of chemoprevention counseling for risk reduction.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Concerns about surgical menopause and loss of fertility are barriers to RRBSO for high-risk women despite understanding the benefits of reduced cancer risk. There is an unmet need for more information about effectively managing the noncancer consequences of RRBSO in premenopausal women. Video Summary:http://links.lww.com/MENO/A478.
Source: Menopause - Category: OBGYN Tags: Original Studies Source Type: research
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