Systems biology and the quest for correlates of protection to guide the development of an HIV vaccine.

Systems biology and the quest for correlates of protection to guide the development of an HIV vaccine. Curr Opin Immunol. 2016 Jul 5;41:91-97 Authors: Kuri-Cervantes L, Fourati S, Canderan G, Sekaly RP Abstract Over the last three decades, a myriad of data has been generated regarding HIV/SIV evolution, immune evasion, immune response, and pathogenesis. Much of this data can be integrated and potentially used to generate a successful vaccine. Although individual approaches have begun to shed light on mechanisms involved in vaccine-conferred protection from infection, true correlates of protection have not yet been identified. The systems biology approach helps unify datasets generated using different techniques and broaden our understanding of HIV immunopathogenesis. Moreover, systems biology is a tool that can provide correlates of protection, which can be targeted for the production of a successful HIV vaccine. PMID: 27392184 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research