TBC2health: a database of experimentally validated health-beneficial effects of tea bioactive compounds.

TBC2health: a database of experimentally validated health-beneficial effects of tea bioactive compounds.
Brief Bioinform. 2016 Jul 6;
Authors: Zhang S, Xuan H, Zhang L, Fu S, Wang Y, Yang H, Tai Y, Song Y, Zhang J, Ho CT, Li S, Wan X
Abstract
Tea is one of the most consumed beverages in the world. Considerable studies show the exceptional health benefits (e.g. antioxidation, cancer prevention) of tea owing to its various bioactive components. However, data from these extensively published papers had not been made available in a central database. To lay a foundation in improving the understanding of healthy tea functions, we established a TBC2health database that currently documents 1338 relationships between 497 tea bioactive compounds and 206 diseases (or phenotypes) manually culled from over 300 published articles. Each entry in TBC2health contains comprehensive information about a bioactive relationship that can be accessed in three aspects: (i) compound information, (ii) disease (or phenotype) information and (iii) evidence and reference. Using the curated bioactive relationships, a bipartite network was reconstructed and the corresponding network (or sub-network) visualization and topological analyses are provided for users. This database has a user-friendly interface for entry browse, search and download. In addition, TBC2health provides a submission page and several useful tools (e.g. BLAST, molecular docking) to facilitate us...

Source: Briefings in Bioinformatics - July 5, 2016 Category: Bioinformatics Authors: Zhang S, Xuan H, Zhang L, Fu S, Wang Y, Yang H, Tai Y, Song Y, Zhang J, Ho CT, Li S, Wan X Tags: Brief Bioinform Source Type: research