In vitro synergistic combinations of pentamidine, polymyxin B, tigecycline and tobramycin with antifungal agents against Fusarium spp.

This study assessed the in vitro susceptibility of 25 clinical isolates of Fusarium against antifungal agents (amphotericin B, caspofungin, itraconazole, and voriconazole) and antimicrobials (pentamidine, polymyxin B, tigecycline, and tobramycin) according to the broth microdilution method (M38-A2). The interactions between antifungal and antimicrobial agents were evaluated by the microdilution checkerboard method. Pentamidine and polymyxin B showed MIC values ≥ 4 µg ml-1 against Fusarium spp. The highest rates of synergism were observed when amphotericin B or voriconazole were combined with tobramycin (80% and 76%, respectively), polymyxin B (76% and 64%), and pentamidine (72% and 68%). The most significant combinations deserve in vivo evaluations in order to verify their potential in the treatment of fusariosis. PMID: 27357655 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research