Vinpocetine improves scopolamine induced learning and memory dysfunction in C57 BL/6J mice.
In this study, we investigated whether vinpocetine could reverse the scopolamine-induced cognitive deficits in animals. Behavioral experiments, including open field, Y-maze, and fear conditioning tests were used to determine the possible role of vinpocetine on scopolamine-induced memory dysfunction. In the open field and Y-maze tests, there were significant differences between the control (CON) group and scopolamine (SCO) group. Vinpocetine (4 mg/kg) administration for consecutive 28 days significantly improved the scopolamine-induced memory dysfunction. In the fear conditioning test, vinpocetine (2 and 4 mg/kg) administration had certain beneficial effect on emotional memory. Our results suggest that vinpocetine could improvement of cognitive function in memory deficient mice and high clinic dosage might be better.
PMID: 27334578 [PubMed - as supplied by publisher]
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Shang Y, Wang L, Li Y, Gu PF Tags: Biol Pharm Bull Source Type: research