Potential of microemulsified entacapone drug delivery systems in the management of acute Parkinson's disease

Conclusions Entacapone S-SMEDDS is an effective drug delivery system that offers more predictable and extensive drug release with enhanced shelf-life in the treatment of acute Parkinsonism.
Source: Journal of Acute Disease - Category: Emergency Medicine Source Type: research

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DiscussionThese findings provide evidence supporting the use of technology-driven interventions aiming at alleviating rhythm-related motor deficits in PD such as hypokinetic dysarthria or gait impairment in complement to more traditional therapeutic approaches.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
Siemens Healthineers is releasing a couple of AI-driven and cloud-based software applications, one for the brain and one for the prostate, that automate a great deal of the manual tasks that radiologists have to perform. Both of the applications can ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Neurology Neurosurgery Radiology Source Type: blogs
ConclusionsThis study provided new evidence that PD with cognitive dysfunction is associated with WM structural alterations. The nodal efficiency and sub-network analyses focusing on the orbitofrontal part might provide new ideas to explore the physiological mechanism of PD-MCI.
Source: Journal of Neurology - Category: Neurology Source Type: research
Conclusions: Diffusion imaging analysis at the early de-novo stage of PD was able to differentiate clinical sub-types of PD after 4.5 years and was highly associated with future clinical outcomes of PD.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
CONCLUSION: DAT-SPECT has been well documented to be highly diagnostically accurate and to have a relevant influence on the diagnosis and treatment of patients with clinically uncertain parkinsonian or tremor syndrome. It has not yet been shown to improve patient-relevant endpoints such as mortality, morbidity, and health-related quality of life; proof of this will probably have to await the introduction of neuroprotective treatments. The current evidence for the high differential diagnostic accuracy of FDG-PET in neurodegenerative parkinsonian syndromes needs to be reinforced by prospective studies with neuropathological ...
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
This study investigated the potential of deep convolutional neural networks (CNN) for automatic classification of FP-CIT SPECT in multi-site or multi-camera settings with variable image characteristics.MethodsThe study included FP-CIT SPECT of 645 subjects from the Parkinson ’s Progression Marker Initiative (PPMI), 207 healthy controls, and 438 Parkinson’s disease patients. SPECT images were smoothed with an isotropic 18-mm Gaussian kernel resulting in 3 different PPMI settings: (i) original (unsmoothed), (ii) smoothed, and (iii) mixed setting comprising all origina l and all smoothed images. A deep CNN with 2,...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
AbstractRationaleIn Parkinson ’s disease (PD), spatial covariance analysis of18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a further validation of the PDRP by applying spatial covariance analysis to PD cohorts from the Netherlands (NL), Italy (IT), and Spain (SP).MethodsThe PDRPNL was previously identified (17 controls, 19 PD) and its expression was determined in 19 healthy controls and 20 PD patients from the Netherlan...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
CONCLUSION: Increased level of glyoxal in diabetes mellitus as well as its high reactivity may cause modifications of the heme protein. Thus, considering the significance of glyoxal-induced protein modification under physiological conditions, the observation appears clinically relevant in terms of understanding hydroimidazolone-mediated protein modification under in vivo conditions. PMID: 31774041 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
In conclusion, AFM is a user-friendly tool that supplies multiparametric data, rendering it a most valuable technique. PMID: 31755391 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Conclusion: We confirmed striatal neurovascular dissociation between FDG-PET and perfusion MRI in response to clinically determined anti-parkinsonian medication. We further proposed a novel analytical method to quantify the degree of dissociation in the putamen using only the ON condition scans, Putamen-to-thalamus Hyper-perfusion/hypo-metabolism Index (PHI), which may have the potential to be used as a biomarker for LID (correctly classifying 8 out 10 patients). For wider use of PHI, a larger validation study is warranted.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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