Hydroxychloroquine, abatacept linked with reduced type 2 diabetes

LONDON – U.S. rheumatoid arthritis patients had a significantly reduced incidence of type 2 diabetes when on treatment with either hydroxychloroquine or abatacept in an analysis of more than 13,000...
Source: Clinical Endocrinology News - Category: Endocrinology Source Type: news

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Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Tao Xian, Yuyang Gan, Yi Lu, Mengxi Wang, Wanwan Yuan, Yumeng Zhou, Junye Chen, Kun Wang, Shaofeng Xiong, Qiren HuangAbstractIndomethacin (IDMT), a non-selective inhibitor of cycloxygenase-2 (COX-2), plays important roles in anti-inflammation and analgesia and it is commonly used to treat the patients with rheumatic and rheumatoid arthritis. Besides, various literatures reported that IDMT is a synthetic ligand of peroxisome proliferator activated receptor gamma (PPARγ). Rosiglitazone (RSG), an insulin-sensitizer, is also a sy...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
A new study has raised the possibility that stress may cause autoimmune disease, such as lupus or rheumatoid arthritis, because it found a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. I have patients who heard about this research and are saying, “I knew it!” But before we accept a potential link between stress and autoimmune disease, let’s look at some details of the study and consider how we define the terms “autoimmune disease,” “stress,” and “stress-related disorder.” What is autoimmune disease? The...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Autoimmune diseases Health Stress Source Type: blogs
Publication date: Available online 6 June 2018Source: Autoimmunity ReviewsAuthor(s): Katrien Van Raemdonck, Sadiq Umar, Zoltán Szekanecz, Ryan K. Zomorrodi, Shiva ShahraraAbstractObesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic di...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Decisions on what method to use should be based on considerations of the route of medication administration, the resources available, setting and aim of the assessment. Combining different methods may provide wider insights into adherence and persistence, including patient behaviour. PMID: 29770718 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
We’ve been told for decades that whole grains are healthy, healthier than processed white flour products. The flawed logic of replacing bad with less bad has thrown off an entire generation of dietitians, physicians, and government agencies charged with providing nutritional advice who have all embraced the less bad whole grains, going as far as urging all of us to make them the dominant ingredient in diet every day. The misconception that whole grains are not just better for you, but healthy is simply not true. If we replace something bad–white flour products–with something less bad–whole grains&nd...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly blood sugar cholesterol diabetes Dr. Davis gluten grain grain-free grains healthy whole-grains joint pain Weight Loss Wheat Belly Total Health whole grains Source Type: blogs
We’ve been told for decades that whole grains are healthy, healthier than processed white flour products. The flawed logic of replacing bad with less bad has thrown off an entire generation of dietitians, physicians, and government agencies charged with providing nutritional advice who have all embraced the less bad whole grains, going as far as urging all of us to make them the dominant ingredient in diet every day. The misconception that whole grains are not just better for you, but healthy is simply not true. If we replace something bad–white flour products–with something less bad–whole grains&nd...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly blood sugar cholesterol diabetes Dr. Davis gluten grain grain-free grains healthy whole-grains joint pain Weight Loss Wheat Belly Total Health whole grains Source Type: blogs
This study set out to clarify the lipid status of antipsychotic naive/minimall y treated FEP, testing the hypothesis that if psychosis is deemed to be an inflammatory condition, then a serological metabolic signature characterized by reduced total and LDL cholesterol should be observed.MethodsA meta-analysis of studies examining lipid parameters in individuals with FEP and no or minimal antipsychotic exposure versus a healthy control group was performed. Studies reported fasting total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and leptin levels.ResultsO...
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research
Abstract Since the successful conquest of many acute, communicable (infectious) diseases through the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and progressive in nature, and are all accompanied by inflammation. These diseases include neurodegenerative (e.g. Alzheimer's, Parkinson's), vascular (e.g. atherosclerosis, pre-eclampsia, type 2 diabetes) and autoimmune (e.g. rheumatoid arthritis and multiple sclerosis) diseases that may appear to have little in common. In fact they all share significant features, in particular chronic inflammation and its attendant inflammatory cyt...
Source: Biological Reviews of the Cambridge Philosophical Society - Category: Biology Authors: Tags: Biol Rev Camb Philos Soc Source Type: research
Obesity is a growing problem worldwide and is associated with a wide range of comorbidities such as type-2 diabetes (T2D), rheumatoid arthritis, cognitive impairment and dementia, hypertension, stroke and heart failure [1]. The global obesity pandemic affects all age groups. A recent study, based on body mass index (BMI) in over 68 million subjects from 195 countries, suggests that prevalence of metabolic diseases was increased in high BMI subjects globally in the past 20  years [2]. The increased BMI has been shown to be pathogenically related to several diseases including cardiovascular and stroke-related diseases [3].
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
CONCLUSIONS: Although further studies are needed to fully investigate the pathogenic interplay between inflammation and metabolic disorders, IL-1β has been implicated in both RA and T2D pathogenic mechanisms. Intriguingly, the potential role of anti-IL-1 drugs has been proposed in RA patients affected by T2D. PMID: 29542422 [PubMed - as supplied by publisher]
Source: Reviews on Recent Clinical Trials - Category: Cancer & Oncology Authors: Tags: Rev Recent Clin Trials Source Type: research
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