Hydroxychloroquine, abatacept linked with reduced type 2 diabetes

LONDON – U.S. rheumatoid arthritis patients had a significantly reduced incidence of type 2 diabetes when on treatment with either hydroxychloroquine or abatacept in an analysis of more than 13,000...
Source: Clinical Endocrinology News - Category: Endocrinology Source Type: news

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Conclusions: In this large population-based study, use of DPP-4 inhibitors was not associated with an increased risk of incident rheumatoid arthritis.
Source: Epidemiology - Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research
MCR, de León AC Abstract Myokines are peptides produced and released by myocytes of muscle fibers that influence physiology of muscle and other organs and tissues. They are involved in mediating the beneficial effects that exercise has on health. More than one hundred have been identified and among them are IL6, myostatin, irisin, mionectin and decorin. Physical inactivity leads to an altered response of the secretion of myokines and resistance to them; this leads to a pro-inflammatory state that favors sarcopenia and fat accumulation, promoting the development of cardiovascular diseases, insulin resistanc...
Source: Immunology Letters - Category: Allergy & Immunology Authors: Tags: Immunol Lett Source Type: research
We wish to share our experience with a rare case of leiomyomatosis peritonealis disseminate LPD, which is a rare condition characterized by the presence of multiple benign smooth muscle nodules located on peritoneal surfaces [1]. A 60  year postmenopausal woman had a 4 month history of abdominal bloating and postmenopausal bleeding, which required a total abdominal hysterectomy with bilateral salpingoopherectomy for a large benign uterine leiomyoma. She was para 3 with a BMI of 31 and medical history included type 2 diabetes me llitus, asthma, and rheumatoid arthritis.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Correspondence Source Type: research
Bioelectronics, generally defined, isn't new. Doctors Rune Elmqvist and Ake Senning implanted the first pacemaker in 1958. FDA approved the first spinal cord stimulator (SCS) in 1989. While both solutions continue to help patients worldwide, smaller, more advanced technology has pushed bioelectronics into a new era. Researchers have developed novel methods to use electrical impulses to regulate the brain and/or nervous system, resulting in highly targeted, effective treatment. "While SCS benefits last as long as the device stimulates, and the pacemaker continually keeps the heart on path, we treat and hope to modify t...
Source: MDDI - Category: Medical Devices Authors: Tags: Implants Electronics Source Type: news
Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Tao Xian, Yuyang Gan, Yi Lu, Mengxi Wang, Wanwan Yuan, Yumeng Zhou, Junye Chen, Kun Wang, Shaofeng Xiong, Qiren HuangAbstractIndomethacin (IDMT), a non-selective inhibitor of cycloxygenase-2 (COX-2), plays important roles in anti-inflammation and analgesia and it is commonly used to treat the patients with rheumatic and rheumatoid arthritis. Besides, various literatures reported that IDMT is a synthetic ligand of peroxisome proliferator activated receptor gamma (PPARγ). Rosiglitazone (RSG), an insulin-sensitizer, is also a sy...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
A new study has raised the possibility that stress may cause autoimmune disease, such as lupus or rheumatoid arthritis, because it found a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. I have patients who heard about this research and are saying, “I knew it!” But before we accept a potential link between stress and autoimmune disease, let’s look at some details of the study and consider how we define the terms “autoimmune disease,” “stress,” and “stress-related disorder.” What is autoimmune disease? The...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Autoimmune diseases Health Stress Source Type: blogs
Publication date: Available online 6 June 2018Source: Autoimmunity ReviewsAuthor(s): Katrien Van Raemdonck, Sadiq Umar, Zoltán Szekanecz, Ryan K. Zomorrodi, Shiva ShahraraAbstractObesity can instigate and sustain a systemic low-grade inflammatory environment that can amplify autoimmune disorders and their associated comorbidities. Metabolic changes and inflammatory factors produced by the adipose tissue have been reported to aggravate autoimmunity and predispose the patient to cardiovascular disease (CVD) and metabolic comorbidities. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are autoimmune arthritic di...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Decisions on what method to use should be based on considerations of the route of medication administration, the resources available, setting and aim of the assessment. Combining different methods may provide wider insights into adherence and persistence, including patient behaviour. PMID: 29770718 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
We’ve been told for decades that whole grains are healthy, healthier than processed white flour products. The flawed logic of replacing bad with less bad has thrown off an entire generation of dietitians, physicians, and government agencies charged with providing nutritional advice who have all embraced the less bad whole grains, going as far as urging all of us to make them the dominant ingredient in diet every day. The misconception that whole grains are not just better for you, but healthy is simply not true. If we replace something bad–white flour products–with something less bad–whole grains&nd...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly blood sugar cholesterol diabetes Dr. Davis gluten grain grain-free grains healthy whole-grains joint pain Weight Loss Wheat Belly Total Health whole grains Source Type: blogs
We’ve been told for decades that whole grains are healthy, healthier than processed white flour products. The flawed logic of replacing bad with less bad has thrown off an entire generation of dietitians, physicians, and government agencies charged with providing nutritional advice who have all embraced the less bad whole grains, going as far as urging all of us to make them the dominant ingredient in diet every day. The misconception that whole grains are not just better for you, but healthy is simply not true. If we replace something bad–white flour products–with something less bad–whole grains&nd...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly blood sugar cholesterol diabetes Dr. Davis gluten grain grain-free grains healthy whole-grains joint pain Weight Loss Wheat Belly Total Health whole grains Source Type: blogs
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