Accumulation of 11C-methionine in the normal pituitary gland on 11C-methionine PET.

CONCLUSION: MET shows strong accumulation in normal pituitary gland. PET/CT would thus be feasible to differentiate between normal and abnormal pituitary glands. PMID: 27273374 [PubMed - as supplied by publisher]
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research

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Authors: Naito Y, Mori J, Tazoe J, Tomida A, Yagyu S, Nakajima H, Iehara T, Tatsuzawa K, Mukai T, Hosoi H Abstract A 14-year-old girl was referred to our department because of headache and visual impairment following the resection of recurrent cardiac myxoma. Head magnetic resonance imaging (MRI) scan detected an intra- and supra-sellar tumor. Moreover, the patient showed the presence of spotty skin pigmentations on her cheeks and lower lip. Blood examination revealed hypothyrotropinemia, and ultrasonography results revealed multiple thyroid nodules. She was diagnosed with Carney complex (CNC). Her pituitary tumor ...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Conclusions: This study provides support for the crossing theory. These findings will inform further finite element models of chiasmal compression. A larger, prospective study is planned.
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
ConclusionWe highlighted how pituitary apoplexy may mimic the clinical findings of an infectious meningoencephalitis, learning points on how clinical assessment can aid earlier diagnosis and the importance of considering this differential diagnosis, particularly with the associated morbidity and mortality.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Conclusions: Normal pituitary SUVmax can be markedly increased on TOF DOTATATE PET imaging compared to previously reported normal ranges derived from non-TOF PET scanners. Furthermore, pituitary microadenomas are not associated with increased, but rather decreased DOTATATE uptake compared to normal pituitary. Additional imaging to investigate high DOTATATE activity in an anatomically normal sella is likely unwarranted.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibit Posters Source Type: research
Conclusions: The feasibility of application of the GBCA on integrated simultaneous PET/MR was notarized and validated on account that the uptake ratio before and after the GBCA injection has not significant changes (P>0.05). Table.1. Average SUV difference between two periods and p value to show the statistical difference significance.cortex regionp valueDif. (%)Prefrontal Lateral R0.8021.36Prefrontal Lateral L0.7081.48Prefrontal Medial R0.8091.03Prefrontal Medial L0.7141.20Sensorimotor R0.8191.13Sensorimotor L0.7251.22Anterior Cingulate R0.7771.22Anterior Cingulate L0.6941.17Posterior Cingulate R0.7341.85Posterior Cing...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Tech Papers IV: Instrumentation & amp; Data Analysis Source Type: research
Conclusions: 68Ga DOTANOC PET/CT was able to localize the source of ectopic ACTH secretion in 38.4% of cases. This study also suggests the possible role of 68Ga DOTANOC PET/CT in detection of residual or recurrent disease on follow-up of known cases of EAS.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: NETs, BAT and All That Source Type: research
Conclusion Although GWAS contributed insight into the utility of the genotype biomarker to treatment selection, adequately powered prospective studies will be required before clinical application of pharmacogenomics can become a reality. Genotype and phenotype assessment should be facilitated by the availability of detailed molecular analyses and data integration. Careful assessment of prospective GWAS data is essential to integrate findings into the clinical decision-making process, and thereby optimizing the treatment of patients with psoriasis in the future. Author Contributions BY, NG, and WY performed the project. ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Conclusions: This is a unique presentation of a pituitary tumor, displaying characteristics of both clinically silent corticotropic and “atypical” macroadenoma subtypes. Although initially ACTH positive while clinically silent, the patient’s disease ultimately recurred metastatically with manifestations of Cushing’s disease and psychosis. With the addition of temozolomide to her treatment plan, her primary and metastatic sit es have responded favorably to radiation therapy. Thus, the addition of temozolomide may be beneficial in the treatment of aggressive pituitary tumors.Case Rep Oncol 2019;12:139 –146
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Immunohistochemistry, confocal microscopy, and double label electron immunocytochemistry confirmed NeuroD1's key role in the pathogenesis of pituitary tumors, regardless of their hormonal state. Its expression level in pituitary adenomas is significantly higher than in the normal pituitary gland and has no reliable correlation with any studied hormones or Ki-67. These findings suggest that NeuroD1 should be investigated further as a potential molecular target in tumor-targeting therapies. PMID: 30719226 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Yamamuro T, Inoue K, Nagai Y, Azuma D, Yamamoto A, Hara K, Kohara M, Iwata T, Nakatsuka S, Morii E, Yamamoto T Abstract Ectopic ACTH syndrome (EAS) is a potentially fatal endocrine disease that results from a variety of neuroendocrine tumors (NETs), such as small cell lung cancer (SCLC) and bronchial typical carcinoid. Typical carcinoid is usually slow growing, not associated with plasma progastrin releasing peptide (ProGRP) elevation. Here, we report a 47-year-old female smoker with progressive typical carcinoid and plasma ProGRP elevation. Several types of Cushingoid features were found on physical exami...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
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