Anaplastic Multiple Myeloma: An aggressive variant with poor response to novel therapies

Anaplastic multiple myeloma is a very rare and aggressive morphologic variant of multiple myeloma with a historically poor prognosis.1 The term anaplastic myeloma is used to describe a plasma cell malignancy involving immature plasma cells of pleomorphic morphology with high grade transformation and extramedullary involvement with large, poorly differentiated cells. 1-3 Anaplastic morphology may be present at time of initial diagnosis or may appear later in the course of disease.4-6 Historically, this disease has been very resistant to chemotherapy.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research