Current and Emerging Therapies of Severe Epileptic Encephalopathies

Recent advances in genetics have markedly impacted our understanding of multiple epilepsy syndromes and is expanding our therapeutic options. Epileptic encephalopathies (EEs) comprise a group of clinical entities each with a specific disease course and with electroencephalographic (EEG) abnormalities that cause progressive disturbances of cerebral functions.1 Failure to appropriately recognize an EE in question results in ongoing cognitive and behavioral impairments. EEs are often resistant to conventional antiepileptic drugs (AEDs), hence the interest in new and emerging therapies.
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research

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Publication date: Available online 1 April 2020Source: Brain StimulationAuthor(s): Jing-Bo Gao, Min Bao
Source: Brain Stimulation - Category: Neurology Source Type: research
Authors: Mégevand P, Seeck M Abstract Introduction: Electric source imaging (ESI) refers to the estimation of the cerebral sources of electric signals recorded at the head surface using electroencephalography (EEG). Thanks to the availability of EEG systems with high numbers of electrodes and to progress in software to analyze the signals they collect, ESI can be applied to epilepsy-related pathological EEG signals like interictal spikes and seizures.Areas covered: In this narrative review, we discuss selected original research articles on the use of ESI in epilepsy patients considered for surgery. Epilepsy-...
Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
Conclusions: RC is reported to be effective in treating a variety of diseases. Current pharmacological studies on RC mainly focus on the nervous, circulatory, digestive, and endocrine systems, as well as drug withdrawal. Although experimental data support the beneficial effects of this drug, its physiological activity remains a concern. Nonetheless, this review provides a foundation for future research. PMID: 32223481 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Pre-eclampsia was associated with a slightly increased risk of epilepsy, autism and other neurodevelopmental problems in offspring.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Preeclampsia Pregnancy and Childbirth Autism Epilepsy Ears and Hearing Intellectual Disabilities Source Type: news
Publication date: Available online 1 April 2020Source: Epilepsy &BehaviorAuthor(s): Alain Braillon
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In this study we report a subtype of ES which is accompanied by two consecutive muscular contractions. This subtype has not been previously classified and may emerge via a complex epileptic network. We named these seizures “epileptic spasms with biphasic muscular contractions (ES-BMC)” and analyzed the association between them and CC outcomes. We enrolled 17 patients with ES who underwent CC before 20 years of age, and analyzed the records of long-term video-electroencephalogram (EEG) recordings. The outcomes of CC were ES-free (Engel's classification I) in 7 and residual ES (II to IV) in 10 patients. We statis...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
OBJECTIVE: Posttraumatic epilepsy (PTE) is a well-described complication of traumatic brain injury (TBI). The majority of the available data regarding PTE stem from the adult population. Our aim was to identify the clinical and radiological risk factors as...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
(Novela Neurotech) A collaboration between Novela Neurotech and NeuroTechX launches a month-long challenge with cash prize for everyone working from home. The challenge aims to harness a new generation of AI and online big data resources to develop better seizure prediction algorithms using scalp EEG signals. Winning solutions will be made available online and open-sourced to encourage further improvements.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We report a 7-year-old boy with this syndrome whose refractory and behavioral abnormalities have been remarkably improved by treatment with LCM.
Source: Brain and Development - Category: Neurology Authors: Tags: Case Report Source Type: research
A variety of neuropeptides play important roles as neurotransmitters or neurotransmitter modifiers in the brain, and may be involved in the incidence and development of epilepsy. In recent years, the following neuropeptides: galanin (GAL), neuropeptide Y (NPY), neuropeptide substance P (SP), cholecystokinin (CCK), as well as wake-promoting neuropeptide (ORE) have been discovered to be closely associated with epilepsy. Vagus nerve stimulation (VNS) is an effective therapy for patients with drug-resistant epilepsy [1].
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
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