Cerebrospinal fluid real‐time quaking‐induced conversion is a robust and reliable test for sporadic creutzfeldt–jakob disease: An international study

Real‐time quaking‐induced conversion (RT‐QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt–Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT‐QuIC is a suitably reliable and robust technique for clinical practice. Ann Neurol 2016

Source: Annals of Neurology - May 31, 2016 Category: Neurology Authors: Lynne I. McGuire, Anna Poleggi, Ilaria Poggiolini, Silvia Suardi, Katarina Grznarova, Song Shi, Bart de Vil, Shannon Sarros, Katsuya Satoh, Keding Cheng, Maria Cramm, Graham Fairfoul, Matthias Schmitz, Inga Zerr, Patrick Cras, Michele Equestre, Fabrizio T Tags: Brief Communication Source Type: research