Abstract B36: Rab25 aggravates cancer cell invasion through Snail expression

Conclusion: Our results show for the first time that Snail mediates Rab25-induced cancer cell EMT and invasiveness through a beta1 integrin /Akt/GSK-3beta signaling cascade, providing novel biomarkers, and potential therapeutic targets for deadly cancers.Citation Format: Bo Young Jeong, Kyung Hwa Cho, Seung Hwa Kim, Yu Na Kim, Chang Gyo Park, Hoi Young Lee. Rab25 aggravates cancer cell invasion through Snail expression. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B36.

Source: Cancer Research - May 25, 2016 Category: Cancer & Oncology Authors: Jeong, B. Y., Cho, K. H., Kim, S. H., Kim, Y. N., Park, C. G., Lee, H. Y. Tags: Metastatic Cell Plasticity Source Type: research