EGFR and DEPTOR in Lung Cancer Progression

This study uncovers the important inhibitory role of DEPTOR in lung adenocarcinoma progression and reveals a novel mechanism that EGFR downregulates DEPTOR expression to facilitate tumor growth.
Implications: DEPTOR acts as a tumor suppressor by limiting EGFR-driven lung adenocarcinoma progression. Mol Cancer Res; 14(5); 448–57. ©2016 AACR.

Source: Molecular Cancer Research - May 11, 2016 Category: Cancer & Oncology Authors: Zhou, X., Guo, J., Ji, Y., Pan, G., Liu, T., Zhu, H., Zhao, J. Tags: Oncogenes and Tumor Suppressors Source Type: research