Approaches for modeling within subject variability in pharmacometric count data analysis: dynamic inter-occasion variability and stochastic differential equations
In this study, two approaches, dynamic inter-occasion variability (dIOV) and adapted stochastic differential equations, were proposed to investigate WSV in pharmacometric count data analysis. These approaches were applied to published count models for seizure counts and Likert pain scores. Both approaches improved the model fits significantly. In addition, stochastic simulation and estimation were used to explore further the capability of the two approaches to diagnose and improve models where existing WSV is not recognized. The results of simulations confirmed the gain in introducing WSV as dIOV and SDEs when parameters vary randomly over time. Further, the approaches were also informative as diagnostics of model misspecification, when parameters changed systematically over time but this was not recognized in the structural model. The proposed approaches in this study offer strategies to characterize WSV and are not restricted to count data.
FYI, limitations are being proposed for Epidural Injection as treatment option for chronic pain This proposed LCD on Epidural Procedures for Pain Management services was announced on June 10, 2021. This nationwide policy contains many onerous changes that will detrimentally affect patient access to care. ASIPP is aware and already contacting congress members, but getting your patients to complain can also help. Please see below for important points but one of the bigger points... Read more
So I'm an applicant for this cycle to pain. I've been fortunate enough to receive 10ish interviews. Im an average applicant and therefore my interviews were from average programs. None of the BWHs and CCs for me. I'm having a hard time coming up with a rank list. I keep wanting to change things around. There is so little information about fellowships outside of interviews that its becoming hard for me to make decisions. Those of you that have gone through the process, what would you... Read more
Anesth/interventional pain MD: Started out at roughly $550K in another state, quit and started up a clinic in Houston ~1.5 years ago. Purchased our building and c-arm. The first year's been tough (credentialing was slow during Covid), but family support and savings (plus having paid off all loans) is helping the start-up efforts now, though growth has been slow. Roughly 50 pts a week, mix of FUs, NPs and some procedures. Mixed payors. Suggestions from any established self-employed solo... Read more
STATINS side effects can include muscle pain, diarrhoea or headaches. Certain foods or drinks consumed may increase your risk of statin side effects.
Pain management product developer Virpax Pharmaceuticals Inc. is planning to raise $40 million through a public stock offering. The Berwyn company plans to sell 6.67 million shares of its common stock at $6 per share. Virpax stock was trading at $5.97 per share Wednesday afternoon. The expected proceeds from the stock sale are more than twice the amount Virpax (NASDAQ: VRPX) raised when it went public in February through its $18 million initial public stock offering. Virpax has granted underwriters…
This post was adapted with permission from the NIH News in Health article, “Staying Safe From Sepsis.” Your immune system is on patrol every day. It protects your body from bacteria, viruses, and other germs. But if something goes wrong, it can also cause big problems. White blood cells undergoing a cascade of biochemical changes that is part of the immune response. Credit: Xiaolei Su, HHMI Whitman Center of the Marine Biological Laboratory. Sepsis happens when your body’s response to an infection spirals out of control. Your body releases molecules into the blood called cytokines to fight the...
ConclusionsThere exist children with cancer whose pain is refractory to the standard approaches and may benefit from IT drug delivery. The existing data, although limited and of low tier evidence, suggest that IT drug delivery has been effective in the pediatric cancer population.
Jack McGeoch, nine, was taken to hospital after suffering with severe abdominal pain and vomiting at his home in Borestone, Stirling, last Tuesday.
ABSTRACT: Infertility, the inability to conceive and/or carry a baby to term, is an agonizing experience for many. Both the experience and pain of infertility are ancient, shared by women and men of the Bible and by couples today. An insider's look into infertility can help nurses understand the suffering that occurs, suggest what can be said and done that can be helpful as well as hurtful, and offer insight into what can be gained personally and spiritually through the experience of infertility.