Two new glycosides isolated from Polygala sibirica L. var. megalopha Fr.

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Ling-Yun Zhou, Jun-Min Wang, Yan-Jie Huang, Xiao-Hong Yu, Bin Lu, Yan Hua Two new glycosides were isolated from the medicinal plant Polygala sibirica L. var. megalopha Fr. The compounds were identified as 2,6-dimethoxy-benzophenone-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside (1) and (6R, 7E, 9R)-9,13-dihydroxy-4,7-megastigmadien-3-one-9-O-[β-D-apiofurano-syl(1→6)-β-d-glucopyranoside (2) using 1D and 2D-NMR spectral data, as well as MALDI-TOF/TOF-MS data. Compounds 1 and 2 were evaluated for their inhibitory activities against xanthine oxidase (XO), and compound 2 showed similar activity to allopurinol, with an IC50 value of 6.48μmol/L. Graphical abstract

Source: Phytochemistry Letters - April 26, 2016 Category: Chemistry Source Type: research