544 A model to evaluate intra-patient differential effects of topical agents in atopic dermatitis

Atopic dermatitis/AD is the most common inflammatory skin disease, with a large unmet need for topical treatments with better efficacy and without long-term side effects associated with topical steroids or calcineurin antagonists. In psoriasis, the plaque test model is valuable for evaluating topical formulations, but has not been evaluated in AD, in which lesions are less stable. To evaluate a novel approach in AD that compares topical agents, we enrolled 30 mild-to-moderate AD patients in a phase I, randomized, vehicle-controlled, double-blinded, intra-individual comparison trial of 3 agents applied daily for 15d: Elidel/El (moderately-active), bethamethasone propionate/BP (potent steroid), clobetasol/CBL (super-potent steroid), and vehicle.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pharmacology & Drug Development Source Type: research