When Myc's asleep, embryonic stem cells are dormant

Myc is one of the original reprogramming factors used to produce induced pluripotent stem cells. However, it is not necessary, instead its main role is to increase the efficiency of the reprogramming. The article by Scognamiglio et al (2016) helps clarify how. The authors show that Myc depletion leads to a reversible dormant state consistent with diapause. In this state, the cell sees its proliferation potential diminished but its pluripotency unchanged. The ability to coordinate the induction of this state should have important implications in cell differentiation.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Development & Differentiation, Stem Cells News [amp ] Views Source Type: research

Related Links:

ConclusionThe finding suggested that LC had the ability to protect neurons by promoting the endogenous proliferation of neuroblast and production of neural differentiation factor in rats after ischemia injury. Meanwhile, LC can anti-neuroinflammation, which is important for the treatment of neuron injury. Accordingly, LC perhaps a promising medicine for neuron damage therapy after cerebral ischemia.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions Despite many promising clinical trials on application of various stem cell–based therapies for treatment of chronic wounds, there is still a need for multicenter comparative studies assessing the dose response and the cell source response on the efficacy of chronic wound healing.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Review Paper Source Type: research
Publication date: Available online 11 November 2019Source: Arthroscopy TechniquesAuthor(s): David Figueroa, Rafael Calvo, Alejandro Vaisman, Sergio Arellano, Francisco Figueroa, Rodrigo Donoso, Nazira Bernal, Luis A. O'ConnellAbstractThe anterior cruciate ligament is the most commonly injured ligament, with up to 10% of surgery failure. Atraumatic instability in the early postoperative period (
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.9b00495
Source: Journal of Proteome Research - Category: Biochemistry Authors: Source Type: research
Source: Revista Brasileira de Cirurgia Cardiovascular - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: van Hugte E, Nadif Kasri N Abstract Neuropsychiatric disorders are a heterogeneous group of disorders that are challenging to model and treat, due to their underlying complex genetic architecture and clinical variability. Presently, increasingly more studies are making use of induced pluripotent stem cell (iPSC)-derived neurons, reprogrammed from patient somatic cells, to model neuropsychiatric disorders. iPSC-derived neurons offer the possibility to recapitulate relevant disease biology in the context of the individual patient genetic background. In addition to disease modeling, iPSC-derived neurons offer...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
As California ’s stem cell research agency prepares to seek another $5.5 billion from taxpayers, local biotech researchers and companies are keeping a close eye on where those dollars go.  The California Institute for Regenerative Medicine was founded in 2004 after voters approved a $3 billion bond issue to f und stem cell research and commercialization across the state. As the agency’s funding is expected to run out this year, backers have proposed a measure for another $5.5 billion bond that…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
ConclusionsOur findings suggest that exosomes derived from GEM-resistant pancreatic cancer stem cells mediate the horizontal transfer of drug-resistant traits to GEM-sensitive pancreatic cancer cells by delivering miR-210.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research
In this report, we demonstrate potent anti‐myeloma effects of the TOPK inhibitor OTS514 for the fir st time. OTS514 induces cell cycle arrest and apoptosis at nanomolar concentrations in a series of human myeloma cell lines (HMCL) and prevents outgrowth of a putative CD138+ stem cell population from MM patient ‐derived peripheral blood mononuclear cells. In bone marrow cells from MM patients, OTS514 treatment exhibited preferential killing of the malignant CD138+ plasma cells compared with the CD138− compartment. In an aggressive mouse xenograft model, OTS964 given orally at 100  mg/kg 5 days per week w...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Ruiz Juan Antonio Marchal María Isabel Núñez Breast cancer is the most common cancer in women. Radiotherapy (RT) is one of the mainstay treatments for cancer but in some cases is not effective. Cancer stem cells (CSCs) within the tumor can be responsible for recurrence and metastasis after RT. Matrix metalloproteases (MMPs), regulated mainly by tissue inhibitors of metalloproteinases (TIMPs) and histone deacetylases (HDACs), may also contribute to tumor development by modifying its activity after RT. The aim of this work was to study the effects of RT on the expression of MMPs, TIMPs and HDACs ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
More News: Molecular Biology | Stem Cell Therapy | Stem Cells