Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis.

CONCLUSION: In light of our previously reported reduced cellular proliferation, cell cycle progression and invasiveness resulting from the LSD1 inhibition in in vitro studies, our data strongly suggest that LSD1 is a promising therapeutic target for endometriosis.
TRIAL REGISTRATION: Not applicable.
PMID: 27062244 [PubMed - in process]

Source: Reproductive Biology - April 13, 2016 Category: Reproduction Medicine Authors: Sun Q, Ding D, Liu X, Guo SW Tags: Reprod Biol Endocrinol Source Type: research