Relationship of body mass index with efficacy of exenatide twice daily added to insulin glargine in patients with type 2 diabetes

Abstract This post hoc analysis assessed the evidence behind common reimbursement practices by evaluating the relationship of body mass index (BMI) ranges (<30, 30–35, and >35 kg/m2) with treatment effects of exenatide twice daily (BID) among patients with type 2 diabetes. Patients received exenatide BID added to insulin glargine in two 30‐week studies (exenatide BID vs insulin lispro, N = 627; exenatide BID vs placebo, N = 259). No relationship of baseline BMI with changes in efficacy parameters was observed. HbA1c reductions were significant (p<0.0001) and similar across BMI range groups in the lispro‐comparator study and greater for exenatide versus placebo in the placebo‐controlled study. Significant weight loss occurred with exenatide across BMI range groups (p < 0.0001), while weight increased with both comparators. Achievement of HbA1c <7.0% (<53 mmol/mol) without weight gain was greater for exenatide versus comparators. Systolic blood pressure decreased across BMI range groups with exenatide in the lispro‐comparator study (p < 0.0001); changes in lipids were not clinically meaningful. Minor hypoglycaemia was less frequent for exenatide versus insulin lispro. These findings suggest that BMI alone should not limit clinical decision‐making or patient access to medication. The studies described are registered with ClinicalTrials.gov, numbers NCT00960661 and NCT00765817.
Source: Diabetes, Obesity and Metabolism - Category: Endocrinology Authors: Tags: RESEARCH LETTER Source Type: research