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VIDEO: Lung transplant rethink urged

The way the transplant system operates for patients who need new lungs is a "scandal" and needs to change, according to the Cystic Fibrosis Trust
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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The aim of this study was to investigate the relationship between dynamic hyperinflation and daily physical activity (DPA) in adults with cystic fibrosis (CF).
Source: BMC Pulmonary Medicine - Category: Respiratory Medicine Authors: Tags: Research article Source Type: research
Conclusions: The present review discusses a novel mechanism for pulmonary edema fluid reabsorption. SPMs might provide new opportunities to design "reabsorption-targeted" therapies with high degrees of precision in controlling ALI/ARDS. PMID: 29664060 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
Conclusion: IT following lung and liver transplantation, with injection of islets into a transplanted organ, is feasible. It improves C-peptide secretion, decreases insulin needs, and lowers HbA1c.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
Hypoglycemia in cystic fibrosis (CF) patients during the oral glucose tolerance test (OGTT) has been reported; however, these patients have not been well-characterized. Few studies have examined whether hypoglycemia during the OGTT increases the risk of developing CF-related diabetes (CFRD). Objectives of this study were to describe the characteristics of CF patients with hypoglycemia during the OGTT and to determine the incidence and time to development of CFRD in those with hypoglycemia.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Abstract An excessive inflammation orchestrated by release of neutrophilic chemokine IL-8 from bronchial epithelial cells, amplified by Pseudomonas aeruginosa (P. aeruginosa) infection, is a hallmark of lung disease of Cystic Fibrosis (CF) patients. To identify novel anti-inflammatory molecular targets, we previously performed a genetic study of 135 genes of the immune response, which identified the c.2534C>T (p.S845L) variant of phospholipase C beta 3 (PLCB3) as being significantly associated with mild progression of pulmonary disease. Silencing PLCB3 revealed that it potentiates the Toll-like Receptor's infla...
Source: American Journal of Respiratory Cell and Molecular Biology - Category: Molecular Biology Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
Condition:   Cystic Fibrosis Interventions:   Drug: PTI-808;   Drug: Placebo;   Drug: PTI-801;   Drug: PTI-428 Sponsor:   Proteostasis Therapeutics, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Lung Transplant Rejection Intervention:   Device: photopheresis Sponsors:   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico;   Italian Cystic Fibrosis Research Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cystic Fibrosis Interventions:   Drug: PTI-808;   Drug: Placebo;   Drug: PTI-801;   Drug: PTI-428 Sponsor:   Proteostasis Therapeutics, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Lung Transplant Rejection Intervention:   Device: photopheresis Sponsors:   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico;   Italian Cystic Fibrosis Research Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the inherited disorder cystic fibrosis (CF). Lung disease is the major cause of CF morbidity, though CFTR expression levels are substantially lower in the airway epithelium than in pancreatic duct and intestinal epithelia, which also show compromised function in CF. Recently developed small molecule therapeutics for CF are highly successful for one specific CFTR mutation and have a positive impact on others. However, the low abundance of CFTR transcripts in the airway limits the opportunity for drugs to correct the defective substrate. E...
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Research Articles Source Type: research
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