Three cytotoxic Annonaceous acetogenins from the seeds of Annona squamosa

Publication date: June 2016 Source:Phytochemistry Letters, Volume 16 Author(s): Yun-Jie Miao, Ye-Ye Shi, Xiao-Fang Xu, Yong Chen, Jian-Wei Chen, Xiang Li Three new Annonaceous acetogenins, squamocin-IV (1), squamocin-V (2) and squamoxinone-E (3), together with seven other known Annonaceous acetogenins (4–10) were isolated from the seeds of Annona squamosa. The structures of all of the isolates were established and characterized through spectral and chemical methods. The new Annonaceous acetogenins 1–3 were evaluated for their cytotoxicity against the Hep-G2, SMMC-7721, BEL-7402, BGC-803 and H460 human cancer cell lines. Compound 3 exhibited the best cytotoxic activity, with IC50 values of 0.103, 0.687, 4.19, 0.43 and 6.56μg/mL, respectively for the cell lines above; meanwhile, Compound 1 showed selective cytotoxic activity against H460, with an IC50 value of 0.049μg/mL. The first mono-ACG (2) composed of 38 carbons was discovered. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research