Molecular Basis of Functional Myocardial Potassium Channel Diversity

Publication date: Available online 24 March 2016 Source:Cardiac Electrophysiology Clinics Author(s): Jeanne M. NerbonneTeaser Multiple types of voltage-gated K+ and non–voltage-gated K+ currents have been distinguished in mammalian cardiac myocytes based on differences in time-dependent and voltage-dependent properties and pharmacologic sensitivities. Many of the genes encoding voltage-gated K+ (Kv) and non–voltage-gated K+ (Kir and K2P) channel pore-forming and accessory subunits are expressed in the heart, and a variety of approaches have been, and continue to be, used to define the molecular determinants of native cardiac K+ channels and to explore the molecular mechanisms controlling the diversity, regulation, and remodeling of these channels in the normal and diseased myocardium.

Source: Cardiac Electrophysiology Clinics - March 23, 2016 Category: Cardiology Source Type: research