Microfluidic Technologies for Yeast Replicative Lifespan Studies

Publication date: Available online 23 March 2016 Source:Mechanisms of Ageing and Development Author(s): Kenneth L Chen, Matthew M Crane, Matt Kaeberlein The budding yeast Saccharomyces cerevisiae has been used as a model organism for the study of aging for over 50 years. In this time, the canonical aging experiment—replicative lifespan analysis by manual microdissection—has remained essentially unchanged. Recently, microfluidic technologies have been developed that may be able to substitute for this time- and labor-intensive procedure. These technologies also allow cell physiology to be observed throughout the entire lifetime. Here, we review these devices, novel observations they have made possible, and some of the current system limitations.

Source: Mechanisms of Ageing and Development - March 23, 2016 Category: Geriatrics Source Type: research