Comparisons between Garcia, modo, and longa rodent stroke Scales: Optimizing resource allocation in rat models of focal middle cerebral artery occlusion

The use of rodent stroke models allow for the understanding of stroke pathophysiology. There is currently no gold standard neurological assessment to measure deficits and recovery from stroke in rodent models. Agreement on a universal preclinical stroke scale allows for comparison of the outcomes among conducted studies. The present study aimed to compare three routinely used neurological assessments in rodent studies (i.e., Garcia, Modo, and Longa) to determine which is most effective for accurately and consistently quantifying neurological deficits in the context of focal middle cerebral artery occlusion (MCAo) in rats.

Source: Journal of the Neurological Sciences - March 19, 2016 Category: Neurology Authors: Salam P. Bachour, Mario Hevesi, Ornina Bachour, Brian M. Sweis, Javad Mahmoudi, Julia A. Brekke, Afshin A. Divani Source Type: research