Ribavirin restores IFN{alpha} responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes

Conclusions
RBV-induced epigenetic changes, leading to decreased ISG expression, restore an IFN-responsive hepatic environment in patients with HCV, which may also prove useful in IFN-free regimens.

Source: Gut - March 9, 2016 Category: Gastroenterology Authors: Testoni, B., Durantel, D., Lebosse, F., Fresquet, J., Helle, F., Negro, F., Donato, M. F., Levrero, M., Zoulim, F. Tags: Hepatology Source Type: research