Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress

Conclusions
SIRT1 is a master regulator of ER stress and severity of experimental colitis in case of MDD. It could deserve further interest as a therapeutic target of IBD.

Source: Gut - March 9, 2016 Category: Gastroenterology Authors: Melhem, H., Hansmannel, F., Bressenot, A., Battaglia-Hsu, S.-F., Billioud, V., Alberto, J. M., Gueant, J. L., Peyrin-Biroulet, L. Tags: Inflammatory bowel disease Source Type: research