Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress

Conclusions SIRT1 is a master regulator of ER stress and severity of experimental colitis in case of MDD. It could deserve further interest as a therapeutic target of IBD.
Source: Gut - Category: Gastroenterology Authors: Tags: Inflammatory bowel disease Source Type: research

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Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
Gastroenterological disorders frequently lead to anaemia as a result of blood loss, inflammation, malabsorption or drug therapies. With malignancy or inflammatory bowel disease, the causes are often multifactorial. Aside from iron deficiency, other conditions resulting in vitamin B12 or folate deficiency can lead to anaemia. Here, coeliac disease, inflammatory bowel disease and surgical resection are particular risk factors. The approach to anaemia in the gastroenterology patient should focus on establishing and managing the underlying cause while supplementing any deficiencies to correct the anaemia.
Source: Medicine - Category: Internal Medicine Authors: Tags: Symptoms and signs Source Type: research
Restorative proctocolectomy (RP) is a common surgical procedure utilized in the management of inflammatory bowel disease (IBD), primarily ulcerative colitis (UC). This procedure involves removal of the colon, and the formation of a pouch from the distal portion of the ileum, the primary site for absorption of vitamin B12. Vitamin B12 deficiency has been linked to fatigue, depression, memory loss, weakness, neuropathy, and altered bowel habits. In RP, surgical manipulation of the ileum, an altered microbiota, and pouchitis may potentially impair vitamin B12 status.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Disease Complications Source Type: research
A deficiency of B12, if left untreated, can lead to irreversible neurological problems.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vitamins Vitamin B12 Anemia Digestive Tract Diet and Nutrition Mental Health and Disorders Celiac Disease Crohn's Disease Source Type: news
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: AGA Abstracts Source Type: research
ConclusionAlthough the overall prevalence of RLS in IBD did not differ to the general population, clinically relevant RLS was more frequent in IBD patients and, therefore, it is important for clinicians to be aware of RLS symptoms. Though for definite diagnosis and proper treatment of RLS, a neurologist must be consulted. Additionally, iron supplementation of IBD patients with ID can improve RLS symptoms.Trial No.NCT03457571
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
A recently published clinical guideline on vitamin and mineral supplements reinforces every other evidence-based guideline, research review, and consensus statement on this topic. The bottom line is that there is absolutely no substitute for a well-balanced diet, which is the ideal source of the vitamins and minerals we need. The brief article, co-authored by nutrition guru Dr. JoAnn Manson, cites multiple large clinical trials studying multiple nutritional supplements’ effects on multiple end points. The gist of it is, our bodies prefer naturally occurring sources of vitamins and minerals. We absorb these better. An...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Drugs and Supplements Health Healthy Eating Prevention Vitamins and supplements Source Type: blogs
All patients with significant gastrointestinal disease should be clinically assessed for protein calorie malnutrition by using the Subjective Global Assessment. Blood tests for anemia, electrolytes, calcium, phosphorus, magnesium, ferritin, vitamin B12, and folate should be considered for assessment of major micronutrients. Where malabsorption or inflammatory bowel disease is diagnosed, bone mineral density using dual beam x-ray absorptiometry, 25-OH vitamin D levels, and measurement of other vitamins and trace elements should be considered. In addition, in at-risk patients, vitamin and trace element clinical deficiency sy...
Source: Gastroenterology Clinics of North America - Category: Gastroenterology Authors: Source Type: research
This study aims to determine the proportion of IBD patients with Cbl concentrations below reference range and their predisposing clinical and genetic characteristics. We then compared this to the proportion with true deficiency. Patients and methods In a prospective observational pilot study of adult IBD outpatients, Cbl concentrations, MMA levels, and fucosyltransferase 2 mutations were measured at clinic visits. Results A total of 66 Crohn’s disease (CD) and 30 ulcerative colitis (UC) patients were recruited. Mean Cbl concentrations (pmol/l) in CD (253.7) were not significantly lower than UC (320.5, P=0.24). ...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Inflammatory Bowel Diseases Source Type: research
Abstract Vitamin B12 deficiency is a common cause of megaloblastic anemia, various neuropsychiatric symptoms, and other clinical manifestations. Screening average-risk adults for vitamin B12 deficiency is not recommended. Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years. Initial laboratory assessment should include a complete blood count ...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
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