Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione.

CONCLUSIONS: 3-BP reacts with GSH in the absence of cells and intracellularly. This reaction appears to be the main cause of GSH loss in 3-BP treated cells.
PMID: 26922560 [PubMed - as supplied by publisher]

Source: Pharmacological Reports - February 29, 2016 Category: Drugs & Pharmacology Authors: Sadowska-Bartosz I, Szewczyk R, Jaremko L, Jaremko M, Bartosz G Tags: Pharmacol Rep Source Type: research