Molecular cytogenetic analysis of chromosome 8 aberrations in multiple myeloma (MM) patients examined in two different stages, at diagnosis and at progression/relapse

Conclusion In the current study, chromosome 8 aberrations were highly heterogeneous, presented at diagnosis in patients with advanced clinical stage and associated with worse overall survival. We have not confirmed the increase of frequency aberration of chromosome 8 in disease progression. The findings demonstrate the importance of FISH examination of chromosome 8 in newly diagnosed MM patients. Teaser This retrospective study of 62 multiple myeloma patients examined at two different phases, at diagnosis and at progression/relapse, revealed chromosome 8 aberrations in 38.7% patients at diagnosis and at progression/relapse in 46.7% patients. We did not confirm significant increase of chromosome 8 aberrations at progression/relapse; however, we confirmed the heterogeneity of the aberrations and poor prognostic impact on overall survival.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research