Variation of topical application to skin under good clinical practice (GCP): A "best performance" scenario.

CONCLUSION: There was a major variation of test ointment application studied under GCP conditions with adherent participants. In dermatological practice, the variation is assumed to be even higher. This should be taken into account in clinical trials, especially dose-finding studies typically operating with 3-5-fold increments. PMID: 26758402 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26758402?dopt=Abstract

Source: Journal of Dermatological Treatment - February 16, 2016 Category: Dermatology Tags: J Dermatolog Treat Source Type: research