Bispecific Antibodies for Targeted Delivery of Dendritic Polyglycerol (dPG) Prodrug Conjugates.

This study demonstrates the potential of digoxigeninylated dPG prodrug conjugates in combination with bsAbs as a new platform for targeted prodrug delivery into cancerous tissues. However the nanoparticle design needs to be further optimized for significant targeted delivery.
PMID: 26853135 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - February 8, 2016 Category: Cancer & Oncology Authors: Mehrabadi FS, Adelmann J, Gupta S, Wedepohl S, Calderón M, Brinkmann U, Haag R Tags: Curr Cancer Drug Targets Source Type: research