The Value of T-SPOT.TB in Early Diagnosis of Tracheobronchial Tuberculosis.

CONCLUSION: T-SPOT.TB can provide important basis for the diagnosis of tracheobronchial tuberculosis.It is the fastest and most accu-rate method in the diagnosis of tracheobronchial tuberculosis. (Sarcoidosis Vasc Diffuse Lung Dis 2015; 32: 336-341). PMID: 26847101 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

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Conclusion: The current accepted criterion for diagnosis of OS may need changes to include such borderline cases due to lack of correlation between clinical and investigative findings. PMID: 30820296 [PubMed]
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Tags: J Ophthalmic Vis Res Source Type: research
Abstract Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the production of ANCAs and systemic necrotizing vasculitis in small vessels. Disordered regulation of neutrophil extracellular traps (NETs) is critically involved in the pathogenesis of AAV. NETs are web-like DNA decorated with antimicrobial proteins; they are extruded from activated neutrophils. The principal degradation factor of NETs in vivo is DNase I; however, NETs resistant to DNase I can persist in tissues and lead to the production of ANCAs. Deposition of NETs has been demonstrated in glomerular crescents ...
Source: Am J Pathol - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
Chronic meningitis is a syndrome defined by the presence of clinical signs and symptoms of meningitis or meningoencephalitis with a persisting cerebral spinal fluid (CSF) pleocytosis that are present for at least 4 weeks. The differential diagnosis is broad, with categories including neoplastic, paraneoplastic, autoimmune, and noninfectious inflammatory disorders and central nervous system (CNS) infections. The exact frequency of the different etiologies often varies tremendously across reports; however, among most institutions, common infectious causes of chronic meningitis includeMycobacterium tuberculosis and fungal men...
Source: JAMA Neurology - Category: Neurology Source Type: research
Sarcoidosis is a systemic, noncaseating, granulomatous disease affecting young adults between the ages of 25 and 40 years, most often of Black origin (35.5/100,000 vs 10.9 in the White population). Although the lower respiratory tract is affected in 90% of cases, ear, nose, and throat locations are very uncommon, with a prevalence varying between 1% and 6.5%.1 In addition, ear, nose, and throat manifestations are nonspecific, and may be difficult to differentiate from other granulomatous diseases such as actinomycosis, aspergillosis, antineutrophil cytoplasmic antibody-associated vasculitis and tuberculosis, thus, frequent...
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
ConclusionWe have reported the first case of clinically manifest retinal vasculitis, associated with a common form of cutaneous vasculitis.
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Authors: Krupa R, Zielonka TM, Hadzik-Blaszczyk M, Wardyn KA, Zycinska K Abstract Fever of unknown origin (FUO) remains one of the most difficult diagnostic challenges. The causes of FUO can be various diseases located in different organs. The aim of the study was to determine the prevalence and nature of pulmonary lesions during FUO. One hundred and sixty one patients with FUO participated in this prospective study. We performed a detailed comprehensive history, physical examination, and a wide spectrum of tests. The most common causes of FUO were infections (39%), autoimmune conditions (28%), and neoplasms (17%)....
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Rationale: Palisaded neutrophilic and granulomatous dermatitis (PNGD) is a benign, inflammatory dermatosis with distinct histopathological features often observed in patients with systemic diseases. There were no reports of PNGD without underlying systemic diseases as an underlying cause of hypercalcemia. Herein, we report a case of a 62-year-old man with hypercalcemia due to PNGD, but with no underlying systemic diseases, including tuberculosis, sarcoidosis, or vasculitis. Patient concerns: Laboratory tests showed an elevated C-reactive protein level, an elevated corrected calcium level, a normal 25-hydroxyvitamin D leve...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion Identification of factors associated with abnormal investigations might improve the optimal diagnostic workup adapted to each patient.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Authors: Tchernev G, Chikoeva AA, Tana M, Tana C Abstract In the article "Transcriptional blood signatures of sarcoidosis, sarcoid-like reactions and tubercolosis and their diagnostic implications" which appeared in Volume 33, Issue 3 (2016) of Sarcoidosis, vasculitis and diffuse lung diseases, the title was given incorrectly. The correct title is "Transcriptional blood signatures of sarcoidosis, sarcoid-like reactions and tuberculosis and their diagnostic implications". PMID: 28079860 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research
Authors: Zhang XQ, Chen GP, Wu SC, Yu S, Wang H, Chen XY, Ren ZC Abstract By analyzing the clinical data of 1 case of IgG4-related lung disease(IgG4-RLD) and the review of literature, the author investigated the clinical characteristics of IgG4-RLD. IgG4-RLD is a rare disease characterized by significant elevation of serum IgG4 and infiltration of a large number of IgG4+ plasma cells. The clinical manifestations of the disease were nonspecific, and the imaging features were mixed with several types. The disease can only be involved in the lung, but also multiple organ involvement. Solely lung-involved IgG4-RD is no...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research
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