Genetic Diversity and Association Studies in US Hispanic/Latino Populations: Applications in the Hispanic Community Health Study/Study of Latinos

US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental exposures. Here, we characterized and controlled for this diversity in genome-wide association studies (GWASs) for the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We simultaneously estimated population-structure principal components (PCs) robust to familial relatedness and pairwise kinship coefficients (KCs) robust to population structure, admixture, and Hardy-Weinberg departures. The PCs revealed substantial genetic differentiation within and among six self-identified background groups (Cuban, Dominican, Puerto Rican, Mexican, and Central and South American).

Source: The American Journal of Human Genetics - January 7, 2016 Category: Genetics & Stem Cells Authors: Matthew P. Conomos, Cecelia A. Laurie, Adrienne M. Stilp, Stephanie M. Gogarten, Caitlin P. McHugh, Sarah C. Nelson, Tamar Sofer, Lindsay Fernández-Rhodes, Anne E. Justice, Mariaelisa Graff, Kristin L. Young, Amanda A. Seyerle, Christy L. Avery Tags: Article Source Type: research