Regulation of TIMP-1 in Human Placenta and Fetal Membranes by lipopolysaccharide and demethylating agent 5-aza-2'-deoxycytidine.

CONCLUSIONS: Collectively, these observations support a potential role for pharmacological agents that modify chromatin structure to be utilized in the therapeutic targeting of TIMP-1 to prevent premature rupture of the fetal membranes in an infectious setting.
PMID: 26691525 [PubMed - in process]

Source: Reproductive Biology - December 26, 2015 Category: Reproduction Medicine Authors: Vincent ZL, Mitchell MD, Ponnampalam AP Tags: Reprod Biol Endocrinol Source Type: research