A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041)

Conclusions The MTD was exceeded at trebananib 10 mg/kg weekly and temsirolimus 20 mg weekly, with frequent overlapping toxicities including fatigue, edema, and anorexia.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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AbstractBackgroundAverage paternal age in the United States has increased substantially in the last few decades. Children of advanced age fathers have a higher incidence of early onset cancer and neuropsychiatric disease.ObjectivesTo quantify the number of population adjusted cases of early ‐onset cancer and neuropsychiatric disease in children attributable to increasing paternal age in the United States.MethodsPaternal age in the United States from 1972 to 2015 was collected using the National Vital Statistics System (NVSS). Population attributable fraction and paternal age ‐specific cumulative incidence rates of seve...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Ever since I was diagnosed with bipolar disorder in 1991, I’ve struggled with my weight. At that time, I weighed 125 and was prescribed lithium to control my highs and lows. The drug worked, but it and other psychotropic drugs contributed to a 20-pound weight gain. Then, as the years went by, I gained the weight that comes with aging. By 40, I weighed about 180. On a 5’3″ frame, this was a lot to carry. I gained even more weight when I struggled with breast cancer in my late 40s and 50s. At 56, I weighed a cool 188 with no clothes on. Recently, I gained even more (I contribute this gain to simply overindu...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anorexia Children and Teens Eating Disorders Habits Health-related Parenting Personal Adolescence Diet Food Addiction Lithium Weight Gain Source Type: blogs
​BY ANGEL BERMUDEZ, MD, &WESLEY EILBERT, MDAn 81-year-old woman with a history of metastatic lung cancer, hypertension, and COPD presented with dizziness that she described as lightheadedness, generalized weakness, and mild shortness of breath for three days. She also reported recent anorexia and a sensation of impending loss of consciousness.She was thin and appeared ill, and she was unable to stand unsupported. She was afebrile with a heart rate of 101 bpm and a blood pressure of 92/55 mm Hg.Her initial ECG is shown. What else could this be if not ST-elevation myocardial infarction?Our patient was found to have a s...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
This study only analyzed the PRQ phases that showed a constant PRQ over a specific period (frequency coupling) and also a phase entrainment between HR and RR (phase coupling) during this time. During sleep, a complex correlation between the HR and the RR is evident with the PRQ capturing one specific aspect. In a study investigating the N-rs-PRQ with a detailed division of the sleep stages (five stages), Zerm et al. (2008) showed that there is a positive correlation between the N-rs-PRQ and the sleep depth, i.e., the higher the depth of sleep, the lower the N-rs-PRQ. In this study, sleep depth was defined according to...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract Gastrointestinal (GI) side effects caused by chemotherapy in women with breast cancer are common but poorly understood which might be controlled by nutritional intervention. Thus, the major aim of this study was to assess the effect of dietary intervention along with nutritional education on reducing these side effects. The present study is a single-center, single-controlled, and randomized trial. A total of 150 patients with breast cancer undergoing chemotherapy were randomly assigned into intervention group to receive dietary intervention and nutritional education (n = 73) or control group...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
Responses to FLT3-inhibitors are usually transient due to emergence of resistance through the acquisition of kinase domain point mutations and other non-mutational mechanisms. SEL is a potent first-in-class Selective Inhibitor of Nuclear Export/SINE™ that exerted marked cell killing of human and murine FLT3-mutant AML cells, including those with ITD, D835Y, ITD+Y842C or ITD+F691L mutations by modulating the cdk inhibitor p27 and anti-apoptotic Mcl-1. The combination of SEL+sorafenib had synergistic pro-apoptotic effects in FLT3-mutated AML cells by suppressing phosphorylation levels of FLT3 and its downstream signali...
Source: Blood - Category: Hematology Authors: Tags: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster I Source Type: research
Sustainable weight loss. Protection from diabetes, heart disease and cancer. Improved brain health. Enhanced physical fitness and strength. It seems like every week, researchers turn up some new and profound benefit associated with intermittent fasting: eating schedules that incorporate regular periods of low or no food consumption. By eating normally for several days a week and eating much less on the others, a person may be able to shift her body’s cellular and metabolic processes in ways that promote optimal health. And experts who study intermittent fasting say that while many blanks still need to be filled in, s...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Diet/Nutrition healthytime Source Type: news
Conclusions: Hospitalized cancer patients in Greece experience several symptoms during the last months of their life. These are influenced by demographic characteristics. Appropriate interventions are strongly advised with appropriate recognition and evaluation of symptoms by health professionals. PMID: 29699055 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
ConclusionsWe found that female breast cancer patients with a prior diagnosis of anorexia nervosa have a worse survival compared with other breast cancer patients.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
AbstractFlammer syndrome (FS) is a prevalent and mostly benign condition. Subjects with FS seem to have a good life expectancy. Nevertheless, FS subjects are at increased risk for certain diseases, mainly when they are challenged by psychological stress or other stimuli such as coldness. FS is related to ocular diseases, such as normal-tension glaucoma, retinitis pigmentosa, central serous chorioretinopathy, optic nerve compartment syndrome, Leber ’s hereditary optic neuropathy, arterial or venous occlusions in the retina, and choroid and optic nerve head, despite the absence of classical vascular risk factors. FS is...
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
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