Shedding light on fundus drusen associated with membranoproliferative glomerulonephritis: breaking stereotypes of types i, ii, and iii

Conclusion: The association of MPGN and drusen needs to be reevaluated. Previously only recognized in association with Type II MPGN, drusen have been demonstrated in 2 patients with C3 glomerulonephritis in this report. These drusen are likely the result of complement pathway abnormalities. The authors propose a new nomenclature in the ophthalmic literature to classify pathology as immune complex-mediated or complement-mediated rather than solely by the electron microscopy findings. This nomenclature will better characterize the underlying genetic abnormalities and pathophysiology of these disease processes.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research