The human milk oligosaccharide 2'-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation

Conclusions
HMOSs and 2'-FL directly inhibit LPS-mediated inflammation during ETEC invasion of T84 and H4 IECs through attenuation of CD14 induction. CD14 expression mediates LPS-TLR4 stimulation of portions of the ‘macrophage migration inhibitory factors’ inflammatory pathway via suppressors of cytokine signalling 2/signal transducer and activator of transcription 3/NF-B. HMOS direct inhibition of inflammation supports its functioning as an innate immune system whereby the mother protects her vulnerable neonate through her milk. 2'-FL, a principal HMOS, quenches inflammatory signalling.

Source: Gut - December 8, 2015 Category: Gastroenterology Authors: He, Y., Liu, S., Kling, D. E., Leone, S., Lawlor, N. T., Huang, Y., Feinberg, S. B., Hill, D. R., Newburg, D. S. Tags: Intestinal inflammation Source Type: research